Development and function of the brain, eye, spinal cord, and peripheral nervous systems can be readily visualized and studied in zebrafish larvae and adults.
The use of transgenic zebrafish lines expressing fluorescent markers in certain subsets of neurons, glia cells, vascular cells, cellular compartments, or proteins (i.e., BBB-transport molecules) provides unique insights into dynamic aspects of cell function during disease progression over time in live animals.
Functional defects in larvae can be studied, for example, as changes in locomotor activity, escape response following a startle stimulus, or by electrophysiological measurements.
Challenge us with proposals for setting up and using new disease models for your drug development project! Our uniquely broad experience in this model system ensures that we will meet that challenge and your expectations.
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