BioReperia´s unique ZTX™ platform provides in-vivo data on tumor regression and metastasis inhibition of compounds.
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The zebrafish at embryo and larval stages is used as modelorganism
At this early stage, the embryo´s immune system is not yet developed, which allows human cells to grow within the embryo without risk of rejection.
At these stages, zebrafish embryos are not considered research animals and do not require ethical permissions for the experiments.
At these stagesofdevelopment, the embryo is transparent, allowing a clear view in the microscope of the growing fluorescent-labeled human cancer cells.
The fast development of the embryo enables rapid vascularization of the developed microtumor, allowing cells to disseminate from the primary tumor site to the vasculature and to the surrounding tissues.
The solid tumorisvascularized within 3 days and allows metastasis invasion, which makes this an excellent tool to screen tumor regression and metastasis invasion.
A tumormicroenvironmentcanbereconstituted within 3 days and allows metastasis invasion, which makes this an excellent tool to screen tumor regression and metastasis invasion.
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