Key publications

Vazquez-Rodriguez G, Abrahamsson A, Jensen LD and Dabrosin C (2017), “Estradiol-induced overexpression of LFA-1 in neutrophils via TGFb-1 promotes breast cancer progression”, Cancer Immunology Research, 5(3), pp. 234-47.

Gnosa S, Capodanno A, Murthy RV, Jensen LD and Sun XF (2016), “AEG1 knock-down in colon cancer cell lines inhibits radiation-enhanced migration and invasion in vitro and in a novel in vivo zebrafish model”, Oncotarget, 7(49), pp. 81634-44.

Rouhi P*, Jensen LD*, Cao Z*, Länne T, Wahlberg E, Steffensen JF and Cao Y, (2010), “Hypoxiainduced metastasis model in embryonic zebrafish”, Nat. Protocols, 5(12), pp. 1911-8

Studying metastasis using ZTX™ models

Mushtaq M, Jensen L, Davidsson S, Grygoruk OV, Andren O, Kashuba V and Kashuba E (2018), “The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells”, Sci. Rep., 8(1), pp. 2268.

Savio M, Ferraro D, Maccario C, Vaccarone R, Jensen LD, Corana F, Mannucci B, Bianchi L, Cao Y and Stivala LA (2016), “Resveratrol analogue 4,4’-dihydroxy-trans-stilbene potently inhibits cancer invasion and metastasis”, Sci. Rep., 6:19973.

Ochoa-Alvarez JA, Krishnan H, Pastorino GJ, Nevel E, Kephart D, Shen Y, Fatahzadeh M, Baredes S, Kalyousef E, Honma M, Adelson ME, Kaneko MK, Kato Y, Yin K, Shienbaum AJ, Jensen LD and Goldberg GS (2015), “Antibody and lectin can target podoplanin to inhibit oral squamous carcinoma cell migration and viability”, Oncotarget, 6(11), pp. 9045-60.

Chen X, Wang J, Cao Z, Jensen L, Yang H, Liu Y and Cao Y (2015), “Invasiveness and metastasis of retinoblastoma in an orthotopic zebrafish tumor model”, Sci. Rep., 5:10351.

Fernández-Barral A, Orgaz JL, Baquero J, Ali Z, Moreno A, Tiana M, Gómez V, Riveiro-Falkenbach E, Cañadas C, Zazov S, Bertolotto C, Davidson I, Rodríguez-Peralto JL, Palmero I, Rojo F, Jensen LD, del Peso L and Jiménez B (2014) ”Regulatory and functional connection of microphthalmia-associated transcription factor and anti-metastatic pigment epithelium derived factor in melanoma”, Neoplasia, 16(6), pp. 529-42.

Gomez-Maldonade L, Tiana, M, Roche O, Prado-Cabrero A, Jensen LD, Fernandex-Barral A, Guijarro-Munoz I, Favaro E, Moreno-Bueno G, Sanz L, Aragones J, Harris A, Volpert O, Jimenez B and del Peso L, (2014) “EFNA3 long non-coding RNAs induced by hypoxia promote metastatic dissemination”, Oncogene, 34(20), pp. 2609-20.

Lee SLC*, Rouhi P*, Dahl Jensen L, Zhang J, Ji H, Hauptmann G, Cao Y, (2009) “Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invation and metastasis in a zebrafish tumor model”, Proc. Natl. Acad. Sci. U S A, 106(46), pp. 19485-90

Studying inter-cellular crosstalk in the tumor microenvironment using ZTX™ models

Vazquez-Rodriguez G, Abrahamsson A, Jensen LD and Dabrosin C (2018), “Adipocytes promote early steps of breast cancer cell dissemination via interleukin-8”, Front. Immunol., 1767.

Ali Z, Islam A, Sherrel P, Le-Moine M, Lolas G, Syrigos K, Rafat M and Jensen LD (2018), “Adjustable delivery of pro-angiogenic FGF-2 by collagen-alginate microspheres”, Biol Open, 7(3):027060.

Liu C, Zhang Y, Lim S, Hosaka K, Yang Y, Pavlova T, Alkasalias T, Harman J, Jensen L, Xing X, Wang X, Lu Y, Nie G and Cao Y (2017), “A zebrafish model discovers a novel mechanism of stromal fibroblast-mediated cancer metastasis”, Clin. Cancer Res., 23(16), pp. 4769-79.

Svensson S, Abrahamsson A, Olsson A-K, Jensen LD, Cao Y and Dabrosin C (2015), ”CCL2 and CCL5 are novel therapeutic targets for estrogen dependent breast cancer”, Clin Cancer Res, 21(16) pp. 3794-805.

Screening using ZTX™ models

Selvaraju K, Mofers A, Pellegrini P, Salomonsson J, Ahlner A, Morad V, Hillert EK, Espinosa B, Arner ESJ, Jensen L, Malmström J, Turkina MV, D’Arcy P, Walters MA, Sunnerhagen M and Linder S (2019), “Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system”, Sci. Rep., 9(1):9841.

Kabakci Z, Käppeli S, Cantú C, Jensen LD, König C, Toggweiler J, Gentili C, Ribaudo G, Zagotto G, Basler K, Pinna LA, Cozza G and Ferrari S (2018), “Pharmacophore-guided discovery of CDC25 inhibitors causing cell cycle arrest and tumor regression”, Sci. Rep. 9(1):1335.

Radiation therapy studied in ZTX™ models

Liu N, Cui W, Jiang X, Zhang Z, Gnosa S, Ali Z, Jensen L, Jönsson JI, Blockhuys S, Lam EWF, Zhao Z, Ping J, Wang X and Sund XF (2019), “The critical role of dysregulated RhoB signaling pathway in radioresistance of colorectal cancer”, Int. J. Radiat. Oncol. Biol. Phys., 104(5), pp. 1153-64.

Other cancer references related to mouse models or clinical cancer research

McDonald PC, Hedlund EM, Nemirovski O, Awrey S, Jensen LD and Dedhar S (2019), “Harnessing induced essentiality: targeting carbonic anhydrase IX and angiogenesis reduces metastasis of triple negative breast cancer xenografts”, Cancers, 11(7):1002.

Oliva D, Jensen L, Sharp L, Nilsson M and Lewin F (2019), “Sleep disturbance after cancer diagnosis and treatment- a multifaceted clinical problem- a pilot study”, J. Neurol. Neurosci, 10(1):284

Hosaka K, Yang Y, Seki T, Nakamura M, Andersson P, Rouhi P, Yang X, Jensen L, Lim S, Feng N, Zue Y, Li X, Larsson O, Ohhashi T and Cao Y, (2013) “Tumor PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodeling and metastasis”. Nature Commun. 8;4:2149

Xue Y, Lim S, Yang Y, Wang Z, Jensen LD, Hedlund EM, Andersson P, Sasahara M, Larsson O, Galter D, Cao R, Hosaka K and Cao Y, (2011) “PDGF-B modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells”, Nature Medicine, 18(1), pp. 100-10.

Reviews and commentaries

Tabebi M, Söderkvist P and Jensen LD (2018), “Hypoxia signaling and circadian disruption in and by pheochromocytoma”, Front. Endocrinol., 9:612.

Krishnan H, Rayes J, Miyashita T, Ishii G, Retzbach EP, Sheehan SA, Takemoto A, Chang YW, Yoneda K, Asai J, Jensen L, Chalise L, Natsume A and Goldberg GS (2018), “Podoplanin – an emerging cancer biomarker and therapeutic target”, Cancer Sci., 76(14), pp. 1215.

Jensen LD (2016), “When tumors are (co-)opting to resist anti-angiogenic treatment”, Transl. Cancer Res., Editorial, 5(7), pp. 1433-36.

Jensen LD (2016), “A circadian PReLude to regulation of angiogenesis and thrombosis by Prolactin and Plasminogen activator inhibitor-1”, Transl. Cancer Res., Editorial, 5(1), pp. 79-82.

Block K et al. (Halifax project participants) (2015), ”A broad-spectrum integrative design for cancer therapy”, Sem. Cancer Biol., 35, pp. S276-304

Hu Z, Brooks SA, Dormou V, Hsu CW, Hsu HY, Lin LT, Massfelder T, Rathmell WK, Xia M, Al-Mulla F, Al-Termaimi R, Amedei A, Brown D, Prudhomme KR, Colacci A, Hamid RA, Mondello C, Raju J, Ryan E, Woodrick J, Scovassi I, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Salem HK, Lowe L, Jensen L, Bisson WH and Kleinstreuer N (2015), “Assesing the carcinogenic potential of low dose exposures to chemical mixtures in the environment: Focus on the cancer hallmark of tumor angiogenesis”, Carcinogenesis, 36 suppl. 1, pp. S184-202.

Wang Z, Dabrosin C, Yin X, Fuster MM, Arreola A, Rathmell KW, Generali D, El-Rayes B, Ribatti D, Chen YC, Honoki K, Fuji H, Georgakilas AG, Nowsheen S, Amedei A, Niccolai A, Amin A, Ashraf SA, Helferich B, Yang X, Guha G, Bhakta D, Ciriolo MR, Aquilano K, Chen S, Halicka D, Mohammed SI, Azmi A and Jensen LD (2015) “Broad targeting of angiogenesis for cancer prevention and therapy”, Sem. Cancer Biol, 35, pp. S224-43

Jensen LD (2015), “The circadian clock and hypoxia in tumor cell de-differentiation and metastasis”, Biochem. Biophys Acta, 1850(8), pp. 1633-41.Jensen LD, Gyllenhaal C and Block KI (2014) "Circadian angiogenesis", Biomolecular Concepts, 5(3), pp. 245-56.

Jensen LD, Gyllenhaal C and Block KI (2014) "Circadian angiogenesis", Biomolecular Concepts, 5(3), pp. 245-56.

Jensen LD, Rouhi P, Cao Z, Länne T, Wahlberg E and Cao Y, (2011), “Zebrafish models to study hypoxia-induced pathological angiogenesis in malignant and non-malignant diseases”, Birth Defects Res C Embryo Today, 93(2), pp. 182-93.

Rouhi P*, Lee SLC*, Cao Z, Hedlund EM, Jensen LD and Cao Y, (2010) “Pathological angiogenesis facilitates tumor cell dissemination and metastasis”, Cell Cycle, 9(5), pp. 913-7

I give BioReperia consent to contact by email or phone for business purpose

Get in touch

Ask your questions or request an introductory call.