Allows identification of drug actions and toxicity under conditions very similar to those in patients. Both general and specific toxicities in zebrafish correlate very well with toxicities in mice and in humans.
Solves problems with fast metabolism of drugs in other animals (i.e., mice) by passive uptake of drugs from the water that results in control over the drug concentration in the embryo.
Provides data in a matter of days. Zebrafish embryos are widely used, faster and less expensive than other in-vivo studies, and more precise than in-vitro experiments.
General toxicology determines tissue-specific and non-specific toxicities from microscopic examination of the larvae over three days.
Specific toxicology determines organ-specific and non-specific toxicities from microscopic examination of the larvae over three days.
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